THE STUDY OF DYNAMICS OF CLINICAL AND MOLECULAR PHENOTYPES IN THE GENERALIZED FORM OF MYASTHENIA WITH OPTIMIZED AND COMBINED TREATMENT

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Abstract

The aim of the study was the research of clinical and molecular phenotypes in the generalized form of myasthenia with optimized treatment, which includes the application of basic mode of the treatment and meglumine sodium succinate, and also the combined mode of the treatment, which includes above the mentioned drugs and ozonotherapy. The most expressed improvement of indicators of the clinical and neurologic status (the elimination of motoring breakdown, eye movement disorders, the weaknesses of mimic, respiratory and chewing muscles, bulbar syndrome, the doubling in eyes and ptosis, pharyngeal violations and increase in volume of movement of eyes) was observed in the group of patients receiving the combined therapy. The reduction of the expressiveness of the defeat of the neuromotor device and the decrement of the amplitude of the various degree of M-answer in patients with myasthenia is revealed in the application of the combined therapy in the comparison with the application of the basic and optimized therapy. For the first time we have investigated the dynamics of the intensity of the expression of specific peptides and proteins in blood serum in patients with the application of basic therapy, reamberin and ozonotherapy, which have allowed to open the new mechanisms of the efficiency of the combined therapy of the disease.

 

About the authors

O. A. Drozd

Rostov state medical university, Rostov-on-Don, Russian Federation

Author for correspondence.
Email: drozd.oksy@gmail.com
PhD student, Department of Nervous Diseases and Neurosurgery, Rostov State Medical University, Resident, Municipal Budgetary Health-Care Institution City Hospital № 8 in Rostov-on-Don Address: 344029, Rostov-on-Don, Nakhichevan Lane, 29; tel.: (863) 250-41-33 Russian Federation

V. V. Efremov

Rostov state medical university, Rostov-on-Don, Russian Federation

Email: drozd.oksy@gmail.com
MD, Neurologist, PhD, Associate Professor, Associate Professor, Department of Nervous Diseases and Neurosurgery, Rostov State Medical University. Address: 344029, Rostov-on-Don, Nakhichevan Lane, 29; tel.: (863) 250-41-33 Russian Federation

M. G. Romantsov

I.I. Mechnikov North-Western State Medical University, Saint-Petersburg, Russian Federation

Email: mr@polysan.ru
Doctor of Medical Science, PhD in Pedagogics, Full Member of the Russian Academy of Natural Sciences. Address: 105037, Moscow, PO Box 47 Russian Federation

I. V. Sarvilina

LLC «Medical centre «Novomeditsina», Rostov-on-Don, Russian Federation

Email: isarvilina@mail.ru
PhD, Clinical Pharmacologist, General Director of Ltd. “Medical Center “Novomeditsina” Address: 344002, Rostov-on-Don, Sotsialisticheskaya St., 74 Russian Federation

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