NEUROPROTECTIVE EFFECTS OF SULFATED POLYSACCHARIDES FROM SEAWEED

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Abstract


Currently, neurodegenerative diseases (NDD) occupy a significant place in the structure of disease of the elderly, which dictates the need to find new and effective treatment and prevention of this pathology. At the heart of NDD development  is a violation of the metabolism and the conformational change of cellular proteins with subsequent accumulation and aggregation of their in  certain groups of neurons. The immediate cause of the death of the affected neurons in NDD is initiated by intracellular proteins apoptosis, during which a large number of neurotransmitter glutamate is released. The consequence of an imbalance in the synthesis and release of neurotransmitters are related  the memory impairment, motor coordination and cognitive abilities of human. Based on the analysis of the extensive literature domestic and predominantly foreign authors of the last decade  the modern data on the effect of sulfated polysaccharides (SPS) of algae in vivo and in vitro in degenerative processes of the nervous system. Found that due to its multi-point impact,   SPS have on the body antioxidant, anti-inflammatory, antiapoptotic, antihyperlipidemic, anti-toxic effects. Consequently, SPS can arrest a number  of secondary pathological effects observed in neurodegenerative diseases (oxidative stress, inflammation, the phenomenon of increased neuronal apoptosis, toxic effects etc.). Varieties of pathogenic mechanisms underlying NDD makes possible the combined use of neuroprotective compounds acting sequentially in different stages of a pathological process. Accumulated a lot of experimental evidence to assume that the SPS  may be the basis for the creation of next-generation drugs for the treatment of neurodegenerative diseases.

 


About the authors

N. N. Besednova

Scientific Research Institute of Epidemiology and Microbiology of Siberian Branch of RAMS, Vladivostok, Russian Federation

Author for correspondence.
Email: besednoff_lev@mail.ru

Russian Federation RAMS academician, Senior Research Worker, Immunilogy Laboratory, G.P. Somova Research Institute of Epidemiology and Microbiology Siberian Branch of RAMS Address: 690087, Vladivostok, Selskaya St., 1; tel.: (423) 244-24-46

L. M. Somova

Scientific Research Institute of Epidemiology and Microbiology of Siberian Branch of RAMS, Vladivostok, Russian Federation

Email: l_somova@mail.ru

Russian Federation PhD, Professor, Senior Research Worker, Laboratory of Pathomorphology and Electron Microscopy, G.P. Somova Research Institute of Epidemiology and Microbiology Siberian Branch of RAMS Address: 690087, Vladivostok, Selskaya St., 1; tel.: (423) 244-14-38

S. A. Gulyaev

Pacific State Medical University, Vladivostok, Russian Federation

Email: s.gulaeva1941@yandex.ru

Russian Federation PhD, Professor, Department of Neurology, Neurosurgery and Medical Genetics, Pacific State Medical University Address: 690002, Vladivostok, Ostryakov av., 2

T. S. Zaporozhets

Scientific Research Institute of Epidemiology and Microbiology of Siberian Branch of RAMS, Vladivostok, Russian Federation

Email: niiem_vl@mail.ru

Russian Federation PhD, Deputy Director for Science, G.P. Somova Research Institute of Epidemiology and Microbiology Siberian Branch of RAMS Address: 690087, Vladivostok, Selskaya St., 1; tel.: (423) 244-24-34

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