MICROBIOTIC FACTOR INFLUENCING THE MONONUCLEAR PHAGOCYTE SYSTEM DEVELOPMENT

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Abstract


Mononuclear-phagocyte system plays an important role in natural immunity and nonspecific resistance reactions of the organism against infection. The experimental studies using conventional laboratory animals with uncontrolled microflora have certain limitations to fully appreciate the role of autoflora (microbiota) in both development and functional activity of mononuclear-phagocyte system. In the present review of the author’ systemic studies the value of microbiologically controlled animals (gnotobiotes) showing the multifaceted role of microbial factor on various manifistations of mononuclear-phagocyte system including phagocytic activity of the cells of both ageing aspects and pathology conditions (inflammation, burns), influence on the colonization resistance and barrier function against translocations of microorganisms from the intestines, temperature reactions and other host defense mechanisms to infection are demonstrated. In a complex body defence, activity of both cellular and humoral factors is being stimulated and modulated by microbiotic factor. Gnotobiotic modeling approach is prospective one for modeling and analysis of molecular and cellular mechanisms in an assessment of the «host-microbiota» interactions, evaluating the effectiveness of new probiotic candidates and further microbial control development in the clinical settings.

 


About the authors

G. I. Podoprigora

Research Institute of Cytochemistry and Molecular Pharmacology, Moscow, Russian Federation

Author for correspondence.
Email: gipodoprigora@yandex.ru

Russian Federation PhD, Professor, Full Member of Academy of Medical and Technical Sciences of the Russian Federation, Director of Research Institute of Cytochemistry and Molecular Pharmacology Address: 115404, Moscow, 6th Radialnaya St., 24/14; tel.: (495) 327-49-87

References

  1. Mononuclear phagocytes. R. van Furth (ed.) Kluwer Academic Publishers: Amsterdam. 1992.
  2. Hume D.A. The mononuclear phagocyte system. Curr. Opin. Immunol. 2006; 18 (1):49–53.
  3. Rabinovitch M. Professional and non-professional phagocytes: an introduction. Trends Cell Biol. 1995; 5: 85–87.
  4. Medzhitov R., Janeway C.A., Jr. Innate immunity: the virtues of a mononclonal system of recognition. Cell. 1997; 91: 295–298.
  5. Schroder K., Jurg T. The Inflammasomes. Cell. 2010; 140: 821–832.
  6. Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2001; 2: 675–680.
  7. Silva М.T. When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system. J. Leukoc. Biol. 2010; 87: 93–106.
  8. Silva M.T., Correia-Neves M. Neutrophils and macrophages: the main partners of phagocyte cell systems. Front. Immunol. 2012; 3: 174.
  9. Wostmann B.S. Germfree and gnotobiotic animal models. Background and applications. CRC Press, Inc., Boca Raton. New York, London, Tokyo. 1996.
  10. Podoprigora G.I., Kafapskaya L.I., Bainov N.A Gnotobiologiya in modern biomedical research. Vestnik RAMN = Annals of RAMS. 2012; 5: 63–70.
  11. Ley R.E., Peterson D.A., Gordon J.I. Ecological and evolutionary forces shaping microbial diversity in the human intes tine. Cell. 2006; 124: 837–848.
  12. O’Hara A.M., Shanahan F. The gut flora as a forgotten organ. EMBO Rep. 2006; 7: 688–693.
  13. Frank D.N., Pace N.R. Gastrointestinal microbiology enters the metagenomics era. Curr. Opin. Gastroenterol. 2008; 24: 4–10.
  14. Podoprigora G.I. Meditsinskaya gnotobiologiya [Medical Gnotobiologiya]. Moscow, MIA, 2003. 271 p.
  15. Podoprigora G.I., Godot V., Harraga S. et al. The host mononuclear phagocyte system (MPS) activity in mice C57BL/6J in an early stage of E. multilocularis infection under experimental treatment. Baltic J. Lab. Anim. Sci. 2002; 12: 143–153.
  16. Podoprigora G.I., Kovtun A.I. Age features of peripheral blood and phagocytosis in gnotobiotic and conventional rats Wistar. Byull. eksp. biol. = Bulletin of experimental biology. 1981; 92 (8): 81–83.
  17. Podoprigora G.I., Zaitsev T.I. Morphological and functional status of elements of the reticuloendothelial system of gnotobiotic animals. Folia Microbiologica. 1979; 24: 55–56.
  18. Podoprigora G.I., Communian L.B., Pimentel E.F.et al. Stimulatory effect of Bifidobacteria on the host mononuclear phagocyte system using gnotobiotic animal models. Anaerobe. 1999; 5: 509–512.
  19. Podoprigora G.I., Communian L.B., Pimentel E.F.et al. Stimulatory effect of gram-positive and gram-negative probiotics on the host mononuclear phagocyte system in gnotobiotic mice. Microecol. Ther. 1999; 28: 177–191.
  20. Andreev V.N., Podoprigora G.I. Effect of non-bacterial associations guinea pigs with individual representatives of the intestinal microflora and the antibody levels of complement. Byull. eksp. biol. – Bulletin of experimental biology. 1976; 82 (9): 1100–1102.
  21. Podoprigora G.I. State of nonspecific resistance in non-bacterial and monokontaminirovannyh miniature pigs. Byull. eksp. biol. – Bulletin of experimental biology. 1978; 9: 341–344.
  22. Podoprigora G.I., Gofman Ya., Yanechek I., Naperstka I. Cyclic 3 ', 5'-adenosine monophosphate in macrophages mucosa and plasma-bacterial and normal animals. Byull. eksp. biol. – Bulletin of experimental biology. 1980; 7: 17–19.
  23. Podoprigora G.I. Barrier-fixing function in animal-bacterial. Byull. eksp. biol. – Bulletin of experimental biology. 1977; 6: 706–709.
  24. Podoprigora G.I. Features aseptic inflammation in non-bacterial guinea pigs. Byull. eksp. biol. – Bulletin of experimental biology. 1970; 11: 35–38.
  25. Podoprigora G.I. The role of microbial factors in non-specific resistance of the host to infection. Microecol. Ther. 1996; 24: 207–217.
  26. Chernukh A.M., Podoprigora G.I., Kranchev A.K. The study of the pathways of E. coli bacteria through the intestinal wall 055 in gnotobiotic and conventional animals. Byull. eksp. biol. – Bulletin of experimental biology. 1978; 86 (6): 654–657.
  27. Podoprigora G.I. Body temperature and reaction to pirogenal in non-bacterial and normal animals. Byull. eksp. biol. – Bulletin of experimental biology. 1978; 3: 263–264.
  28. Fedorov N.A., Koryakina I.K., Podoprigora G.I. The study of the nature of toxic factors for burns in a gnotobiotic experiment. Byull. eksp. biol. – Bulletin of experimental biology. 1973; 10: 81–84.
  29. Podoprigora G.I. Phagocytic activity of the mononuclear phagocyte system in gnotobiotic animals under conditions of aging and experimental burn injury. Microecol. Ther. 1990; 20: 203–211.
  30. Isakov Yu.F., Stepanov E.A., Podoprigora G.I., Nemsadze V.P., Ginodman G.A. Gnotobiologiya v khirurgii [Gnotobiology in Surgery]. Moscow, Meditsina, 1982. 223 p.
  31. Kusunoki R., Ishihara S., Aziz M., Oka A., Tada Y., Kinoshita Y. Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation. Digestion. 2012; 85:103–107.
  32. Zak D.E., Aderem А. Systems biology of innate immunity. Immunol. Rev. 2009; 227(1): 264–282.

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