INVASIVE STREPTOCOCCAL (GROUP A) INFECTION OF SOFT TISSUES IN A MOSCOW SURGICAL HOSPITAL

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Abstract

Aim. To study features and risk factors  of soft tissue's invasive streptococcal infection in surgical unit's patients: a) emm-types of the most often recovered streptococcus; b) human immune response for streptococcal antigens (streptolysin-O and the group A carbohydrate antigen); c) main patient's conditions that complicate the course of soft tissue's streptococcal infection. Patients and methods. 101 surgical unit's patients with soft tissue's infection, which group A streptococcal (GAS) nature, were examined. Emm-types were determined by comparison of emm gene sequenced part with data of CDC Streptococcus Laboratory. ASO and specific anti-group-carbohydrate IgM were measured with photometry and ELISA accordingly.  Patient’s personal data were analyzed by standard statistical programs. Results. Among 34 emm-types of all streptococcal isolates emm28 and emm64 were registered only in invasive infection.  Emm-types 1, 49, 60, 66, 77, 84, 88 were most often. Among 23 sera from invasive GAS-infection's patients, 15 (65%) were ASO-negative, 6 (26%) were ASO-low-positive, and 2 (8%) were positive, but negative for the anti-group-A-carbohydrate IgM. Conclusion. Lower levels of the humoral immune response as well as risk factors such as trauma, alcoholism, diabetes, chronic venous insufficiency contributed to development of severe forms of GAS-infection. The main streptococcal emm-types for soft tissue's invasive GAS infection in one of Moscow surgical unit's patients in 2008-2011 were registered.

 

About the authors

N. I. Briko

I.M. Sechenov First Moscow State Medical University, Russian Federation

Author for correspondence.
Email: briko@mma.ru
Professor, RAMS academician, Head of the Department of Epidemiology and Evidence-Based Medicine, Head of the Laboratory for the development of new technologies of epidemiological surveillance and control of infectious diseases, I.M. Sechenov First Moscow State Medical University. Address: 119992, Moscow, Trubetskaya St., 8/2; tel. / fax: (499) 248-04-13 Russian Federation

E. V. Glushkova

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: ekaterina-1801@mail.ru
PhD student, Research Worker, Laboratory for the development of new technologies of epidemiological surveillance and control of infectious diseases, I.M. Sechenov First Moscow State Medical University. Address: 119992, Moscow, Trubetskaya St., 8/2; tel.: (499) 248 69 28 Russian Federation

N. F. Dmitrieva

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: dmitrieva@mma.ru
PhD, Leading Research Worker, Laboratory for the development of new technologies of epidemiological surveillance and control of infectious diseases, I.M. Sechenov First Moscow State Medical University. Address: 119992, Moscow, Trubetskaya St., 8/2 Russian Federation

D. A. Kleimenov

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: 10000let@rambler.ru
PhD, Senior Research Worker, Laboratory for the development of new technologies of epidemiological surveillance and control of infectious diseases, I.M. Sechenov First Moscow State Medical University. Address: 119992, Moscow, Trubetskaya St., 8/2; tel.: (499) 248-69-28 Russian Federation

K. V. Lipatov

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: k_lipatov@mail.ru
PhD, Professor, Department of General Surgery, I.M. Sechenov First Moscow State Medical University Address: 119992, Moscow, Trubetskaya St., 8/2; tel.: (499) 248-69-28 Russian Federation

A. S. Eshchina

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: briko@mma.ru
PhD, Leading Research Worker, Laboratory for the development of new technologies of epidemiological surveillance and control of infectious diseases, I.M. Sechenov First Moscow State Medical University. Address: 119992, Moscow, Trubetskaya St., 8/2; tel.: (499) 248-69-28 Russian Federation

Yu. M. Timofeev

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: ua3ahh@mail.ru
PhD, Senior Research Worker, Laboratory for the development of new technologies of epidemiological surveillance and control of infectious diseases, I.M. Sechenov First Moscow State Medical University. Address: 119992, Moscow, Trubetskaya St., 8/2; tel.: (499) -248-69-28 Russian Federation

M. A. Mirskaya

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: mmirskaya@mail.ru
MD, Bacteriologist, City Clinical Hospital № 23 named after "Medsantrud" Address: 119027, Moscow, Yauzskaya St., 11/6; tel.: (495) 915-38-51 Russian Federation

O. V. Vvedenskaya

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: superpinkpanter@mail.ru
PhD student, Department of General Surgery, I.M. Sechenov First Moscow State Medical University. Address: 119992, Moscow, Trubetskaya St., 8/2 Russian Federation

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