GLUTATHION AS AN IMPORTANT COMPONENT OF THIOSULFID SYSTEM OF INFERTILITY PATHOGENESIS IN OVERWEIGHT MEN

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Abstract

Aim: to study the glutathionic part of thiosulfid system and oxidative stress in infertile men with different body mass index. Patients and methods: examined 60 infertile men with normal and overweight, and 40 healthy men with proven fertility. Active components of the antioxidant defense system of the body was assessed by the level of reduced and oxidized glutathione by the method of PY Hissin, determination of TBA-active products was carried out by the method VB Gavrilova. In the analysis of inter-group differences for independent samples was used parametric Student criterion. Results: the oxidative stress in obese men was characterized by significant elevation of oxidized form of glutathione (GSSG) in comparison with its reduced form. We discussed our results in the context of GSSG «quantivalence» to numerous of cellular processes in the setting of metabolic disorders in infertile and obese men. The ratio of reduced glutathione to oxidized infertile men decreased by 1,5 times in patients with obesity and 1,2 times in those with normal body mass index. Conclusions: Glutathione is the most important link in the study of oxidative stress in men with infertility. Raising the level of oxidized glutathione is due to the presence of his additional functions that are implemented at higher values of body mass index, especially in association with infertility.

 

About the authors

L. I. Kolesnikova

Scientific Center of the Problems of Family Health and Human Reproduction, Irkutsk, Russian Federation

Author for correspondence.
Email: iphr@sbamsr.irk.ru

PhD, Professor, RAMS academician, Director of the Scientific Center of Family Health and Human Reproduction Problems, Siberian Branch of Russian Academy of Medical Sciences
Address: 664003, Irkutsk, Timiryazeva Street, 16; tel.: (3952) 20-76-36, 20-73-67

Russian Federation

O. A. Vanteeva

Scientific Center of the Problems of Family Health and Human Reproduction, Irkutsk, Russian Federation

Email: olga_tolpygina@mail.ru
PhD student, Scientific Center of Family Health and Human Reproduction Problems, Siberian Branch of Russian Academy of Medical Sciences
Address: 664003, Irkutsk, Timiryazeva Street, 16; tel.: (3952) 20-76-36
Russian Federation

N. A. Kurashova

Scientific Center of the Problems of Family Health and Human Reproduction, Irkutsk, Russian Federation

Email: nakurashova@yandex.ru

PhD, Research Worker, Scientific Center of Family Health and Human Reproduction Problems, Siberian Branch of Russian Academy of Medical Sciences
Address: 664003, Irkutsk, Timiryazeva Street, 16; tel.: (3952) 20-76-36

Russian Federation

B. Ya. Vlasov

Scientific Center of the Problems of Family Health and Human Reproduction, Irkutsk, Russian Federation

Email: iphr@sbamsr.irk.ru

PhD, Professor, Senior Research Worker, Laboratory of Physiology and Pathology of endocrine system, Scientific Center of Family Health and Human Reproduction Problems, Siberian Branch of Russian Academy of Medical Sciences
Address: 664003, Irkutsk, Timiryazeva Street, 16; tel.: (3952) 20-76-36, 20-73-67

Russian Federation

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