The Value of Trabecular Bone Score in Patients with Rheumatic Diseases

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Background. Trabecular bone score obtained by lumbar spine Dual-energy X-ray Absorptiometry is a novel and insufficiently explored instrument of accessing trabecular bone quality. One of its promising applications is early diagnostics of osteoporosis (OP) before fragility fractures appear. Meanwhile most of systemic inflammatory rheumatic diseases affect bone tissue either directly and indirectly by glucocorticoids consumption. Both factors potentiate OP development and can influence the trabecular bone score. 

Aims — to evaluate the possibilities of trabecular bone score using in rheumatology. 

Materials and Methods. Data analysis of domestic and foreign scientific publications. 

Results and Discussion. Authors of analyzed publications note stable association of low trabecular bone score with vertebral fractures, its correlation with local inflammatory markers in lumbar spine and ankylosing spondylitis structural progression. In most studies trabecular bone score do not have association with systemic inflammatory activity and treatment. 

Conclusion. Trabecular bone score is effective in OP diagnostics in rheumatic patients, evaluation of local inflammatory activity in the lumbar spine and structural progression of ankylosing spondylitis.

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About the authors

Konstantin I. Kolpakov

Research Institute of Clinical and Experimental Lymphology — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Author for correspondence.
ORCID iD: 0000-0002-6834-2651
Russian Federation, 10, Lavrentjev avenue, 630090, Novosibirsk

Maxim A. Korolev

Research Institute of Clinical and Experimental Lymphology — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

ORCID iD: 0000-0002-4890-0847
SPIN-code: 5494-7355

MD, PhD, Associate Professor

Russian Federation, 10, Lavrentjev avenue, 630090, Novosibirsk

Yuliya B. Ubshaeva

Research Institute of Clinical and Experimental Lymphology — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

ORCID iD: 0000-0001-6330-1044


Russian Federation, 10, Lavrentjev avenue, 630090, Novosibirsk


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Supplementary files

Supplementary Files
1. Fig. 1. Dual-energy X-ray absorptiometry, anteroposterior projection of the lumbar spine. Differences in TBS in two different patients with nearly identical BMD

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