Immunological Aspects of Normal and Pathological Pregnancy

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Abstract

This article presents an overview of foreign and domestic data (Web of Science, e-LIBRARY, Scopus, PubMed) for the period 1998–2021, devoted to the system of immune protection of the mother and fetus during normal and pathologically occurring pregnancy. According to the results of the analysis of the literature data, changes occurring at the level of cellular and humoral immunity were revealed, and the mechanisms of innate and adaptive immunity, complement systems in such pathologies of pregnancy as miscarriage, threat of termination, preeclampsia, infectious complications were described. A complex system of protection against fetal rejection is a certain regulatory factor in maintaining the immunological balance during the entire gestation period, and a violation in its work underlies the formation of complications of the early and late postpartum period, as well as neonatal pathologies.

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About the authors

Daria E. Galkina

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: dashsemch@mail.ru
ORCID iD: 0000-0001-7516-5203
SPIN-code: 4757-7940
Scopus Author ID: 57203807050
ResearcherId: AAJ-2991-2020

MD, PhD, Associate Professor

Russian Federation, zd. 1, Partizan Zheleznyak str., 660022, Krasnoyarsk

Tatyana A. Makarenko

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Email: makarenko7777@yandex.ru
ORCID iD: 0000-0002-2899-8103
SPIN-code: 3133-7406
ResearcherId: AAJ-2216-2020

MD, PhD, Associate Professor

Russian Federation, zd. 1, Partizan Zheleznyak str., 660022, Krasnoyarsk

Dmitry V. Okladnikov

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky

Author for correspondence.
Email: okladdm@yandex.ru
ORCID iD: 0000-0003-3212-7957
SPIN-code: 4971-5250
Scopus Author ID: 614951

MD, PhD, Associate Professor

Russian Federation, zd. 1, Partizan Zheleznyak str., 660022, Krasnoyarsk

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1. Fig.1.

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2. Fig.2. Schematic representation of HLA loci on the sixth chromosome

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