AGE AND SEXUAL CHANGES STRUCTURE OF GENES CYTOKINES NETWORKS IN RUSSIAN POPULATION

Cover Page


Cite item

Full Text

Abstract

Objective: to study frequencies of occurrence of the combined genetic attributes including different variants of cytokines genotypes (TNFA, IL1B, IL4, IL6, IL10, VEGF), in different on sexual  and age groups in population of Siberia Caucasoid. Material and methods. Frequencies of distribution of variants of structure genes cytokines networks  among 500 representatives of Siberia  Caucasian population, men and women  of  two age groups - more younger than 35 years ("young") and 55 and more years ("elderly") are  investigated. In structure of  investigated genes cytokines net  has come 10 variants of polymorphic sites of cytokines genes and  vascular endothelial growth factor gene: TNFА-863 C→A, TNFА-308 G→A, TNFА-238 G→A, IL1B-31 С→T, IL4-590 С→T, IL6-174 G→C, IL10-1082 G → A, IL10-592 А→С, VEGF-2578 C→A and VEGF+936 С→T. Genotyping are carried out by  restriction fragment length polymorphism method. Processing of results carried out on the basis of the original methodological approach including the complex connected computer analysis of genic circuits of various dimension. Results and conclusions. It is shown, that the significant part of variants genes cytokines networks, which   widely distributed among young people is completely absent in the "elderly" age group. Such variants disappearing with age separately for men and women are established. At the program mathematical analysis it is established, that parameters of the odds ratio  achieve two-place sizes (OR =27, p =0,0004), that testifies to high specificity of complex genetic attributes. Presence in genome such variants of genes cytokines networks  , found out in the childhood or young age, as supposed, is unfavorable personalized prognostic factors of life span of the individual.

 

About the authors

V. I. Konenkov

Scientific Research Institute of Clinical And Experimental Limfology RAMS, Novosibirsk, Russian Federation

Author for correspondence.
Email: konenkov@soramn.ru
PhD, professor, member of RAMS, Head of the Clinical Immunogenetics Laboratory, director of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94 Russian Federation

V. F. Prokof'ev

Scientific Research Institute of Clinical And Experimental Limfology RAMS, Novosibirsk, Russian Federation

Email: vprok@ngs.ru
MD, leading research scientist of the Clinical Immunogenetics Laboratory of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94 Russian Federation

A. V. Shevchenko

Scientific Research Institute of Clinical And Experimental Limfology RAMS, Novosibirsk, Russian Federation

Email: shalla64@mail.ru
MD, senior research scientist of the Clinical Immunogenetics Laboratory of the Scientific Research Institute of clinical and experimental lymphology under the Siberian Branch of RAMS. Address: 2, Timakova St., Novosibirsk, 630117, tel.: (383) 227-01-94 Russian Federation

A. M. Chernyavskii

Scientific Research Institute of a Pathology of Blood Circulation named after E.N. Meshalkin of the Health Ministries of Russian Federation, Novosibirsk, Russian Federation

Email: tsvelo@mail.ru
PhD, professor, Head of the Center of Aortic Surgery, coronary and peripheral arteries of the Federal State Budgetary Institution E. N. Meshalkin Scientific Research Institute of circulation pathology of The Ministry of Health of the Russian Federation. Address: 15, Rechkunovskaya St., Novosibirsk, 630055, tel.: (383) 332-47-58 Russian Federation

A. M. Karas'kov

Scientific Research Institute of a Pathology of Blood Circulation named after E.N. Meshalkin of the Health Ministries of Russian Federation, Novosibirsk, Russian Federation

Email: tsvelo@mail.ru
PhD, professor, member of RAMS, director of the Federal State Budgetary Institution E. N. Meshalkin Scientific Research Institute of circulation pathology of The Ministry of Health of the Russian Federation. Address: 15, Rechkunovskaya St., Novosibirsk, 630055, tel.: (383) 332-47-58 Russian Federation

References

  1. Strategiya razvitiya meditsinskoi nauki v Rossiiskoi Federatsii na period do 2025 goda. [The Strategy for the Development of Medical Science in the Russian Federation for the Period up to 2025]. Moscow, Ministry of Health of the Russian Federation, 2012. 17 p.
  2. Konenkov V.I., Korolev M.A., Shevchenko A.V., Lapsina S.A., Koroleva E.A., Zonova E.V., Prokof'ev V.F. Cytokine gene polymorphism with type 2 diabetes in women of Caucasoid origin in Russia. Terapevticheskii Arkhiv = Therapeutic Archive. 2012; 10(84): 14–22.
  3. Konenkov V.I., Shevchenko A.V., Prokof'ev V.F., Maksimov V.N. Complex genotypes of cytokines as a genetic risk factor for myocardial infarction in men Caucasoid population of Russia. Kardiologiya = Cardiology. 2012; 7: 22–29.
  4. Konenkov V.I., Shevchenko A.V., Prokof'ev V.F., Golovanova O.V. Comparative genetics promoters of cytokine genes Caucasoid population of Russia. Meditsinskaya immunologiya = Medical immunology. 2011; 4–5(13): 539–540.
  5. Konenkov V.I. Cytokine complex polygenic - markers customize status cytokine network healthy person and patients with diseases of different nature. Allergologija = Allergology. 2011; 2(12): 191–194.
  6. Konenkov V.I., Golovanova O.V., Prokof'ev V.F., Shevchenko A.V., Zonova E.V., Korolev M.A., Leonova Yu.B., Khalaidzhi N.A., Lapsina S.A. The distribution of allelic variants of the promoter regions of cytokine genes and gene vascular endothelial growth factor in healthy people and patients with rheumatoid arthritis in a population of Caucasoid population of Russia. Vestnik RAMN = Annals of the RAMS. 2010; 9: 9–14.
  7. Shevchenko A.V., Konenkov V.I., Golovanova O.V., Blagodatskikh A.E., Stakheeva M.N. Gene polymorphism VEGFA (C-2578A, C + 936T) in patients with breast cancer. Meditsinskaya immunologiya = Medical immunology. 2012; 1–2(14): 87–94.
  8. Kolchanov N.А. Computer functional genomics: description and modeling of gene expression. Molekulyarnaya biologiya = Molecular biology. 2004; 4(38): 738–739.
  9. Konenkov V.I., Prokof'ev V.F., Shevchenko A.V., Golovanova O.V. Cytokine gene polymorphism as a factor in the demographic structure of Caucasoid population of Siberia. Immunologiya = Immunology. 2011; 2: 60–65.
  10. Weir B. Analiz geneticheskikh dannykh. Diskretnyye geneticheskiye priznaki. [Genetic Data Analysis: Methods for Discrete Population Genetic Data. Transl. from English.]. Мoscow, Mir, 1995. 400 p.
  11. Pevnitskii L.А. Statistical evaluation of associations HLA-antigens with diseases. Vestnik AMN SSSR = Annals of AMS of the USSR. 1998; 7: 48–51.
  12. Glants S. Mediko-biologicheskaya statistika. [Medical and Biological Statistics. Transl. from English]. Мoscow, Praktika, 1998. 459 p.
  13. Konenkov V.I., Shkurat G.A., Kolesnikov A.P. Molecular and pathophysiological mechanisms of regulation of lymphangiogenesis. Uspekhi sovremennoy biologii – Advances in Current Biology. 2012; 2(132): 155–166.
  14. Poveshchenko O.V., Poveshchenko A.F., Konenkov V.I. Physiological and cytological bases of cellular regulation of angiogenesis. Uspekhi fiziologicheskikh nauk = Advances in Physiological Sciences. 2012; 3(43): 48–61.
  15. Poveshchenko A.F., Konenkov V.I. Mechanisms and angiogenesis factors. Uspekhi fiziologicheskikh nauk = Advances in Physiological Sciences. 2010; 2(41): 69–89.
  16. Roshchina N.V., Pasyukova E.G. Genes that regulate the development and functioning of the nervous system, determine the life span of Drosophila melanogaster. Genetika = Genetics. 2007; 43: 356–362.
  17. Beekman M., Blanche H., Perola M., Hervonen A., Bezrukov V., Sikora E., et al. GENA consortium. Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell. 2013; 12(2): 184-93.
  18. Capri M., Salvioli S., Sevini F., Valensin S., Celani L., Monti D., Pawelec G., De Benedictis G., Gonos E.S., Franceschini C. Understanding and Modulating Aging. Annals of the New York Academy of Sciences. 2006; 5(1067): 252-263.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 1970 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies