COVID-19, hemostasis disorders and risk of thrombotic complications

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The spread of a new coronavirus infection worldwide since the end of 2019 has becomes a pandemic. Thrombotic complications are the leading cause of death in this disease. After entering the human body, the virus starts a cascade of reactions leading to the development of a cytokine storm, activation of all parts of the hemostasis and complement systems and other changes that result in disturbances in the circulation system with the development of multiple organ failures. Numerous studies have shown that a predictor of a severe course of COVID-19 is a sharp increase of D-dimer concentration in the blood and rise of some other markers of hemostasis activation. Based on the pathogenesis, the developed schemes for the prevention and treatment of COVID-19 severe complications include low molecular weight heparins (LMWH) which are also recommended for an outpatient COVID-19 patient. The prescription of low molecular weight heparin, the duration of their use and doses should be decided on the basis of a risk assessment of factors for each individual patient in combination with laboratory monitoring.

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About the authors

Alexander D. Makatsariya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
ORCID iD: 0000-0001-7415-4633
SPIN-code: 7538-2966
Scopus Author ID: 6602363216
ResearcherId: M-5660-2016

MD, PhD, Professor

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

Ekaterina V. Slukhanchuk

Petrovsky National Research Center of Surgery

ORCID iD: 0000-0001-7441-2778
SPIN-code: 7423-8944

MD, PhD, Assistant Professor

Russian Federation, 2, Abrikosovsky pereulok, Moscow, 119991

Victoria O. Bitsadze

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID iD: 0000-0001-8404-1042
SPIN-code: 5930-0859
Scopus Author ID: 6506003478
ResearcherId: F-8409-2017

MD, PhD, Professor

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

Jamilya Kh. Khizroeva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID iD: 0000-0002-0725-9686
SPIN-code: 8225-4976
Scopus Author ID: 57194547147
ResearcherId: F-8384-2017
Mendeley Profile:

MD, PhD, Professor

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

Maria V. Tretyakova

Medical Center LLC

ORCID iD: 0000-0002-3628-0804
SPIN-code: 1463-0065

MD, PhD, Assistant Professor

Russian Federation, Timura Frunze str.15/1, 119021, Moscow

Valentina I. Tsibizova

Almazov National Medical Research Centre

ORCID iD: 0000-0001-5888-0774

Doctor, Departments of Functional and Ultrasound Diagnostics

Russian Federation, 2 Akkuratova str., Saint- Petersburg, 197341

Andrei S. Shkoda

LA Vorokhobov City Clinical Hospital 67

ORCID iD: 0000-0002-9783-1796


Russian Federation, Moscow

Elvira Grandone

I.M. Sechenov Moscow State Medical University, (Sechenov University); Thrombosis and Haemostasis Research Unit, Fondazione I.R.C.C.S. “Casa Sollievo della Soff erenza”

ORCID iD: 0000-0002-8980-9783
Scopus Author ID: 7006391091

MD, PhD, Professor

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992; San Giovanni Rotondo, FG, Italy

Ismail Elalamy

I.M. Sechenov Moscow State Medical University (Sechenov University); Medicine Sorbonne University, University Hospital Tenon

ORCID iD: 0000-0002-9576-1368
Scopus Author ID: 7003652413

MD, PhD, Professor

Russian Federation, Trubetskaya str. 8-2, 119991; rue de la Chine 75970 Paris Cédex 20, France

Giuseppe Rizzo

I.M. Sechenov First Moscow State Medical University (Sechenov University); University of Roma Tor Vergata

ORCID iD: 0000-0002-5525-4353
Scopus Author ID: 7102724281
ResearcherId: G-8234-2018

MD, PhD, Professor

Russian Federation, Trubetskaya str. 8-2, 119991, Moscow; Ospedale Cristo Re 00167 Roma Italy

Jean-Christophe R. Gris

I.M. Sechenov Moscow State Medical University, (Sechenov University); University Montpellier

ORCID iD: 0000-0002-9899-9910
Scopus Author ID: 7005114260

MD, PhD, Professor

France, 8-2, Trubetskaya street, Moscow, 119992; Montpellier, France

Sam Schulman

I.M. Sechenov Moscow State Medical University, (Sechenov University); Thrombosis and Atherosclerosis Research Institute, McMaster University

ORCID iD: 0000-0002-8512-9043
Scopus Author ID: 55792310000

д.м.н., профессор

Canada, 8-2, Trubetskaya street, Moscow, 119992; Hamilton, Ontario, Canada

Benjamin Brenner

I.M. Sechenov Moscow State Medical University, (Sechenov University); Rambam Health Care Campus


MD, PhD, Professor

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992; Haifa, Israel


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