FORWARD-MORPHOLOGICAL CRITERIA OF ULCERATIVE COLITIS RELAPSE AND CONTINUOUS FLOW IN CHILDREN

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Abstract

Inflammatory bowel disease is one of the most difficult groups of pathologies in pediatric gastroenterology, due to the steady growth of their prevalence, offset debut at an earlier age, the increase in the incidence of severe complicated forms. Established clinical, genetic, serologic criteria for progression of ulcerative colitis are contradictory, and some - the reach of most medical institutions. Aim: to evaluate the prognostic significance of morphological features of ulcerative colitis relapse and continuous flow. Materials and methods: a retrospective study conducted histological kolonobioptatov 26 children with recurrent, 20 - with a continuous flow of ulcerative colitis during their primary treatment in a hospital, the comparison group consisted of 50 children without inflammatory bowel disease. Results: morphological characteristics identified predictors of recurrent ulcerative colitis in the form of severe eosinophilic infiltration of the epithelium, lamina propria of the mucosa. For a continuous flow was characterized: high density cell infiltration of the lamina propria mucosa epithelium predominantly under represented plasma cells, fibroblasts, sclerosis of the basal membrane, the presence of epithelial arcades deformed crypt abscesses. Conclusion: the extended study of biopsy material, including assessment of the composition and location of infiltration, fibroblast pool of epithelial- connective relationships in the colonic mucosa of children with ulcerative colitis will not only assess the inflammatory process, but also to predict the course of disease, thereby defining a long-term tactics treatment.

 

About the authors

E. N. Fedulova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Author for correspondence.
Email: fedulova04@mail.ru
MD, Head of the Department of large bowel pathology clinic of FSBI “Nizhny Novgorod Research Institute of Pediatric Gastroenterology” of the Ministry of Health of Russian Federation. Address: 22, Semashko St., Nizhny Novgorod, 603950, tel.: (831) 436-67-06 Russian Federation

E. A. Zhukova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: fedulova04@mail.ru
PhD, professor, Deputy director of scientific work of FSBI “Nizhny Novgorod Research Institute of Pediatric Gastroenterology” of the Ministry of Health of Russian Federation. Address: 22, Semashko St., Nizhny Novgorod, 603950, tel.: (831) 436-62-46 Russian Federation

T. A. Kuznetsova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: fedulova04@mail.ru
MD, research scientist of the Morphological Laboratory of FSBI “Nizhny Novgorod Research Institute of Pediatric Gastroenterology” of the Ministry of Health of Russian Federation. Address: 22, Semashko St., Nizhny Novgorod, 603950, tel.: (831) 436-93-39 Russian Federation

O. V. Shumilova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: shumilovaolya0502@mail.ru
junior research scientist of the Department of large bowel pathology clinic of FSBI “Nizhny Novgorod Research Institute of Pediatric Gastroenterology” of the Ministry of Health of Russian Federation. Address: Semashko St., 22, Nizhny Novgorod, 603950, tel.: (831) 436-67-06 Russian Federation

O. V. Fedorova

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: olgafedorva@mail.ru
senior research scientist the Department of large bowel pathology clinic of FSBI “Nizhny Novgorod Research Institute of Pediatric Gastroenterology” of the Ministry of Health of Russian Federation. Address: 22, Semashko St., Nizhny Novgorod, 603950, tel.: (831) 436-67-06 Russian Federation

O. A. Tutina

Nizhny Novgorod Research Institute of Pediatric Gastroenterology, Russian Federation

Email: tutina_oa@mail.ru
MD, research scientist of the Department of large bowel pathology clinic of FSBI “Nizhny Novgorod Research Institute of Pediatric Gastroenterology” of the Ministry of Health of Russian Federation. Address: 22, Semashko St., Nizhny Novgorod, 603950, tel.: (831) 436-67-06 Russian Federation

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