CHARACTERISTICS OF THE СOURSE OF MAXILLARY SINUSITIS IN CHILDREN WITH VERIFIED CHLAMYDIA INFECTION

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Abstract

Aim. To explore the detection rate of chlamydia infection and immunological features of children with acute maxillary sinusitis. Patients and methods. Сlinical epidemiologic characteristics of the course of acute maxillary sinusitis were studied in the way of medical examination provided for 58 children in the ages from 3 to 15 years, patients of ENT department. In order to identify Chlamydia structures and specific antibodies we used direct (polymerase-chain reaction, direct immune fluorescence) and indirect (immune enzyme analysis) methods. The research for cellular link of immunity was carried out by indirect immune fluorescence technique, using monoclonal antibodies. Results. The authors report on high level of Chlamydia infection in epithelium of nasal mucosa, and also type structure of verified Chlamydia, clinical signs and peculiarities of immune response in children with acute maxillary sinusitis associated with this infection. Conclusions: Chlamydia was detected in 48 % of children with acute maxillary sinusitis infection with prevalence of Chlamydophila pneumoniae. Optimal for detection of chlamydia infection is a disease duration not exceeding 2 weeks. The special features of clinical and immunological manifestations in children with acute sinusitis, paired with Chlamydia infection are the more frequent complaints of pain in the affected sinuses, expressed symptoms of intoxication, and the presence of an imbalance in cellular immunity , manifested a relative lymphopenia and activation of T-lymphocytes CD8+.

 

About the authors

T. A. Kapustina

Medical Scientific Research Institute for Northern Problems of the Siberian Branch of RAMS, Krasnoyarsk, Russian Federation

Author for correspondence.
Email: tak34@yandex.ru
PhD, research adviser of the clinical department of pathology of upper respiratory tract of FSBI “Scientific Research Institute of Medical Problems of the North” under the Siberian Branch of RAMS. Address: 3g, Partizana Zheleznyaka St., Krasnoyarsk, 660022, tel.: (3912) 228-06-62 Russian Federation

E. V. Belova

Medical Scientific Research Institute for Northern Problems of the Siberian Branch of RAMS, Krasnoyarsk, Russian Federation

Email: belova.ev@bk.ru
MD, senior research scientist of the clinical department of pathology of upper respiratory tract of FSBI “Scientific Research Institute of Medical Problems of the North” under the Siberian Branch of RAMS. Address: 3g, Partizana Zheleznyaka St., Krasnoyarsk, 660022, tel.: (3912) 228-06-62 Russian Federation

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