Remodeling of the Heart of the Premature Child

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Epidemiological studies consistently have suggested an association between low birth weight and increased rate of cardiovascular morbidity and mortality in adult life. Preterm birth, as one of the leading causes of the low birth weight, is associated with cardiovascular remodeling which consists of changes in heart chambers geometry and contraction-relaxation mode, ventricular hypertrophy, arterial wall structure and density changes. Several types of preterm birth are discussed: prematurity, associated with placental insufficiency and fetal growth restriction, preterm leaking of amniotic fluid, and twin pregnancy. DNA methylation process under the influence of epigenetic factors of the intrauterine and early postnatal development is suggested as a one of the main mechanism of cardiovascular remodeling in preterm infants. The other mechanisms of cardiovascular remodeling are discussed in terms of the modern intrauterine programming concept. The early diagnostics and prevention of cardiovascular diseases in preterm born children are discussed. The treatment during prenatal and early postnatal periods as well as prevention of the remodeling causes could diminish and even reverse the development of the negative cardiovascular events and diseases in later life according to the so called concept of “one thousand days opportunities window”.

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O. P. Kovtun

Ural State Medical University

ORCID iD: 0000-0002-5250-7351
SPIN-code: 9919-9048
Scopus Author ID: 23980378200

MD, PhD, Professor

Russian Federation, Ekaterinburg

P. B. Tsyvian

Ural State Medical University; Mother and Child Care Research Institute

Author for correspondence.
ORCID iD: 0000-0002-8186-6329
SPIN-code: 1750-0200

 MD, PhD, Professor


Russian Federation, Ekaterinburg

T. V. Markova

Mother and Child Care Research Institute

ORCID iD: 0000-0002-4882-8494
SPIN-code: 1782-9104



Russian Federation, Ekaterinburg

T. V. Chumarnaya

Institute of Immunology and Physiology Ural branch of Russian Academy of Sciences; Ural Federal University

ORCID iD: 0000-0002-7965-2364
SPIN-code: 7978-8955
Scopus Author ID: 36105839400

PhD in Biology

Russian Federation, Ekaterinburg


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