DEVELOPMENT OF MOTOR FUNCTIONS AND MANUAL ABILITIES IN PEDIATRIC PATIENTS WITH SPASTIC CEREBRAL PALSY AFTER BOTULINUM TOXIN TREATMENT AND COMPLEX REHABILITATION

Cover Page
  • Authors: Klochkova O.A.1, Kurenkov A.L.1, Namazova-Baranova L.S.2, Mamed'yarov A.M.1, Zherdev K.V.1
  • Affiliations:
    1. Scientific Centre of Children Health of RAMS, Moscow, Russian Federarion
    2. Scientific Centre of Children Health of RAMS, Moscow, Russian Federarion I.M. Sechenov First Moscow Medical State University, Russian Federation N.I. Pirogov Russian National Scientific Research Medical University, Moscow, Russian Federation
  • Issue: Vol 68, No 11 (2013)
  • Pages: 38-48
  • Section: PEDIATRICS: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/121
  • DOI: https://doi.org/10.15690/vramn.v68i11.842
  • Cite item

Abstract


Aim: to investigate the dynamic of general motor function and manual abilities in children with spastic forms of cerebral palsy (CP) after complex rehabilitation combined with single and repeated injections of botulinum toxin A (BTA). Patients and methods: the article presents 18 month follow-up of 52 patients with mono- and bilateral spastic forms of CP after single and multiple injections of botulinum toxin A and complex rehabilitation/ Patients received totally 74 injection sessions: 17 (32,7%) children — twice, 5 (9,6%) children — three times. Motor development assessment was done according to the GMFCS and GMFMS-88 scales and centile curves of normal motor development connected with these scales, hand function was classified according to the MACS scale. For the first time results of botulinum toxin therapy and rehabilitation were compared with the natural motor development of patients with different levels of motor disturbances according to centile tables. Results: patients with bilateral cerebral palsy improved slowly than hemiparetic and changes lasted for longer period. Level according to the MACS scale didn’t depend on the gestational age of the patients, was higher in children with hemiparesis and changed for 1 level in 4 (7,7%) patients after the first botulinum toxin A injections.

 


About the authors

O. A. Klochkova

Scientific Centre of Children Health of RAMS, Moscow, Russian Federarion

Author for correspondence.
Email: Klochkova_oa@nczd.ru

Russian Federation pediatrician of the Department of Remedial Treatment of Children with Nervous System Diseases of Research Institute of Preventive Pediatrics and Remedial Treatment of FSBI SCCH of RAMS. Address: build. 1, 2, Lomonosov Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-01-69

A. L. Kurenkov

Scientific Centre of Children Health of RAMS, Moscow, Russian Federarion

Email: kurenkov@nczd.ru

Russian Federation PhD, leading research scientist of the Department of Psychoneurology and psychosomatic pathology of Research Institute of Pediatrics of FSBI SCCH of RAMS. Address: build. 1, 2, Lomonosov Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-04-09

L. S. Namazova-Baranova

Scientific Centre of Children Health of RAMS, Moscow, Russian Federarion
I.M. Sechenov First Moscow Medical State University, Russian Federation
N.I. Pirogov Russian National Scientific Research Medical University, Moscow, Russian Federation

Email: namazova@nczd.ru

Russian Federation PhD, professor, correspondent member of RAMS, Director of Research Institute of Preventive Pediatrics and Remedial Treatment of FSBI SCCH of RAMS. Address: build. 1, 2, Lomonosov Avenue, Moscow, RF, 119991; tel.: +7 (495) 967-14-14

A. M. Mamed'yarov

Scientific Centre of Children Health of RAMS, Moscow, Russian Federarion

Email: amm@nczd.ru

Russian Federation MD, Head of the Department of Remedial Treatment of Children with Nervous System Diseases of Research Institute of Preventive Pediatrics and Remedial Treatment of FSBI SCCH of RAMS. Address: build. 1, 2, Lomonosov Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-01-69

K. V. Zherdev

Scientific Centre of Children Health of RAMS, Moscow, Russian Federarion

Email: zherdev@nczd.ru

Russian Federation MD, Head of the Department of Neuroorthopedics and orthopedics of Research Institute of Pediatrics of FSBI SCCH of RAMS. Address: build. 1, 2, Lomonosov Avenue, Moscow, RF, 119991; tel.: +7 (499) 134-07-63

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