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CLINICAL-ANAMNESTIC AND MOLECULAR-GENETIC FACTORS IN DIFFERENT FORMS OF HYPERTENSION AND ITS RELATIONSHIP TO COURSE AND PREGNANCY OUTCOMES
- Authors: Chulkov V.S.1, Vereina N.K.1, Sinitsyn S.P.1, Dolgushina V.F.1
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Affiliations:
- South Ural State Medical University, Chelyabinsk, Russian Federation
- Issue: Vol 68, No 11 (2013)
- Pages: 22-25
- Section: OBSTETRICS AND GYNAECOLOGY: CURRENT ISSUES
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/117
- DOI: https://doi.org/10.15690/vramn.v68i11.838
- ID: 117
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Abstract
Aim: to assess of the relationship of clinical and molecular genetic factors in the course and outcome of pregnancy in different forms of hypertension in pregnant women. Patients and methods: a total of 125 pregnant women who were divided into the following groups: with chronic hypertension (n =45), with gestational hypertension (n =20), with pre-eclampsia (n =10), superimposed preeclampsia upon chronic hypertension (n =15) and 35 women without hypertension in control group. Results: in pregnant women with chronic hypertension and superimposed preeclampsia upon chronic hypertension were observed higher incidence of overweight and obesity, smoking before pregnancy and family history of hypertension and thrombosis, the course and outcomes of pregnancy characterized by higher frequency of obstetric complications, higher frequency of polymorphisms of genes identified the renin-angiotensin system, folate cycle and endothelial function. Conclusions: Molecular-genetic factors, combined with the factors of cardiovascular risk may make some contribution to the phenotypic realization of pregnancy complications and adverse pregnancy outcomes in pregnant women with different forms of hypertension.
About the authors
V. S. Chulkov
South Ural State Medical University, Chelyabinsk, Russian Federation
Author for correspondence.
Email: vschulkov@rambler.ru
MD, assistant professor of the Department of Intermediate Level Therapy of Yuzhno-Ural’skii State Medical University. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092, tel.: (351) 253-65-71, e-mail: vschulkov@rambler.ru Russian Federation
N. K. Vereina
South Ural State Medical University, Chelyabinsk, Russian Federation
Email: vereinank@is74.ru
PhD, professor of the Department of Intermediate Level Therapy of Yuzhno-Ural’skii State Medical University. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092, tel.: (351) 253-65-71 Russian Federation
S. P. Sinitsyn
South Ural State Medical University, Chelyabinsk, Russian Federation
Email: sinitsinsp@is74.ru
PhD, professor, Head of the Department of Intermediate Level Therapy of Yuzhno-Ural’skii State Medical University. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092, tel.: (351) 253-69-29 Russian Federation
V. F. Dolgushina
South Ural State Medical University, Chelyabinsk, Russian Federation
Email: kanc@chelsma.ru
PhD, PhD, professor, Head of the Department of Obsterics and Gynecology of YuzhnoUral’skii State Medical University. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092, tel.: (351) 232-73-71 Russian Federation
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