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In the present review modern data about change of morfo-functional properties of a trophoblast during pregnancy, and also about influence of the cytokines produced by cells of a microenvironment, including leucocytes of mother, on a functional state of trophoblast is cited. Features of interaction between trophoblast and immune cells of mother are described within physiological pregnancy and within pregnancy complicated by preeclampsia.


About the authors

E. K. Ailamazyan

D.O. Ott Research Institute of Obstetrics and Gynecology North-West Branch under the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

Author for correspondence.
Email: iag@ott.ru
PhD, professor, academician of RAMS, Honoured scientist of Russian Federation, Director of FSBI “D. O. Ott Research Institute of Obstetrics and Gynecology”, Russian Academy of Medical Sciences. Address: 3, Mendeleevskaya line, St. Petersburg, RF, 199034, tel.: (812) 325-32-20 Russian Federation

O. I. Stepanova

D.O. Ott Research Institute of Obstetrics and Gynecology North-West Branch under the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

Email: alzas@mail.ru
MD, research scientist of Laboratory of Immunology of FSBI “D. O. Ott Research Institute of Obstetrics and Gynecology”, Russian Academy of Medical Sciences. Address: 3, Mendeleevskaya line, St. Petersburg, RF, 199034, tel.: (812) 323-75-45 Russian Federation

S. A. Sel'kov

D.O. Ott Research Institute of Obstetrics and Gynecology North-West Branch under the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

Email: elkovsa@mail.ru
PhD, professor, Head of Laboratory of Immunology of FSBI “D. O. Ott Research Institute of Obstetrics and Gynecology”, Russian Academy of Medical Sciences. Address: 3, Mendeleevskaya line, St. Petersburg, RF, 199034, tel.: (812) 323-75-45 Russian Federation

D. I. Sokolov

D.O. Ott Research Institute of Obstetrics and Gynecology North-West Branch under the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

Email: falcojugger@yandex.ru
PhD, leading research scientist of Laboratory of Immunology of FSBI “D. O. Ott Research Institute of Obstetrics and Gynecology”, Russian Academy of Medical Sciences. Address: 3, Mendeleevskaya line, St. Petersburg, RF, 199034, tel.: (812) 323-75-45, (812) 328-98-50 Russian Federation


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