THE CONCEPT OF INFECTIOUS DISEASES PATHOGENESIS

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Abstract


In this article a concept of infectious disease pathogenesis as consisted with clinical symptoms is provided. The course of disease, immediate and long term consequences depend on the mode of entry. If the infection comes via oropharynx, airway, gastrointestinal tract or via skin, the immune system provides adequate immune response. This leads to typical symptoms, cyclical clinic progression and usually to the recovery with the formation of full sterile immunity. In case of parenteral way of infection, which includes perinatal way, there is no full mode of entry, the disease takes chronic course involving visceral organs because of different mechanisms of affinity and new tropic organ involving. For the full sanogenesis germ or its mediators should persist in the primary focus of infection. It is suggested, that HIV, HCV, hepatitis B virus, tetanus, rabies and other infectious diseases with inner organs involvement, as well as all slow infections, should be treated as infectious diseases with the parental way of infection, proceeding with affinity changings, which lead to the appearance of new tropic sites in visceral organs. The theory of the mode of entry, affinity, appearance of tropic sites in visceral organs should form the basis of modern infectology.


About the authors

V. F. Uchaikin

Pirogov Russian National Research Medical University, Moscow, Russian Federation

Author for correspondence.
Email: uchaikin@list.ru

Russian Federation PhD, professor, academician of RAMS, Head of the 1st Department of Infectious Diseases in Children of Pediatric Faculty of FBEI HPE “N.I. Pirogov Russian National Research Medical University”. Address: 1, Ostravityanov Street, Moscow, RF, 117997; tel.: +7 (916) 123-44-80

O. V. Shamsheva

Pirogov Russian National Research Medical University, Moscow, Russian Federation

Email: ch-infection@mail.ru

Russian Federation PhD, professor, Head of the 2nd Department of Infectious Diseases in Children of Pediatric Faculty of FBEI HPE “N.I. Pirogov Russian National Research Medical University”. Address: 1, Ostravityanov Street, Moscow, RF, 117997; tel.: +7 (916) 516-22-57

References

  1. Sherlok Sh., Duli G. Zabolevaniya pecheni i zhelchnykh putei [Diseases of Liver and Biliary Tract]. 1999. 864 p.
  2. Uchaikin V.F., Cherednichenko T.V., Smirnov A.V. Infektsionnaya gepatologiya [Infection Hepatology]. Moscow, GEOTAR-Media, 2012. 640 p.
  3. Maier K.-P. Gepatit i posledstviya gepatita [Hepatites and its Effects]. 1999. 432 p.
  4. Uchaikin V.F., Nisevich N.I., Cherednichenko T.V. Virusnye gepatity ot A do TTV u detei [Viral Hepatitis from A to TTV in Children]. Moscow, Novaya volna, 2003. 432 p.

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