CHANGES OF EPIDERMAL GROWTH FACTOR LEVEL IN BLOOD SERUM, SALIVA AND GASTRIC JUICE IN CHILDREN WITH DUODENAL ULCER

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Abstract

92 children, age 8-17 years, with duodenum ulcer were under observation. The peculiarities of EGF level changes in human biological mediums, depending on phase of the disease. The highest EGF level was detected with acute peptic ulcer in the presence of ulcerous defects. EGF level increasing was marked out in the remission phases ulcerous defects healing, and it didn`t reach normal values in gastric juice. EGF content changes in biological mediums were revealed with different variants of duodenum ulcer clinical course in children. The lowest EGF level was marked out in blood, saliva and gastric juice with unfavorable course of the disease (frequent relapses, cicatricial-ulcerous strains formation), which can serve as a prognostic factor.

About the authors

E. A. Zhukova

Federal State Establishment “Nizhniy Novgorod Research Institute of Children Gastroenterology”, Nizhniy Novgorod, Russia

Author for correspondence.
Email: zhulenn@mail.ru
PhD, Deputy Director for Research work of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-62-46 Russian Federation

T. A. Vidmanova

Federal State Establishment “Nizhniy Novgorod Research Institute of Children Gastroenterology”, Nizhniy Novgorod, Russia

Email: talev2001@mail.ru
MD, Head of Clinic of Upper Parts of Digestive Tract Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-15-90 Russian Federation

I. N. Viskova

Federal State Establishment “Nizhniy Novgorod Research Institute of Children Gastroenterology”, Nizhniy Novgorod, Russia

Email: niidg@mail.ru
postgraduate student of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-15-90 Russian Federation

S. A. Kolesov

Federal State Establishment “Nizhniy Novgorod Research Institute of Children Gastroenterology”, Nizhniy Novgorod, Russia

Email: niidg@mail.ru
MD, senior research scientist of Laboratorial and Diagnostic Department of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-54-60 Russian Federation

L. V. Korkotashvili

Federal State Establishment “Nizhniy Novgorod Research Institute of Children Gastroenterology”, Nizhniy Novgorod, Russia

Email: lvkor@inbox.ru
MD, Head of Laboratorial and Diagnostic Department of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-54-60 Russian Federation

N. Yu. Shirokova

Federal State Establishment “Nizhniy Novgorod Research Institute of Children Gastroenterology”, Nizhniy Novgorod, Russia

Email: niidg@mail.ru
MD, senior research scientist of Morphology Group of the Laboratorial and Diagnostic Department of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-93-39 Russian Federation

N. Yu. Kan'kova

Federal State Establishment “Nizhniy Novgorod Research Institute of Children Gastroenterology”, Nizhniy Novgorod, Russia

Email: nelly.kankova@gmail.com
MD, research scientist of Clinic of Upper Parts of Digestive Tract Pathology of FSBI “Nizhnii Novgorod Research Institute of Pediatric Gastroenterology” of Ministry of Health, Russian Federation. Address: 22, Semashko Street, Nizhny Novgorod, RF, 603950, 22; tel.: +7 (831) 436-15-90 Russian Federation

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