The Use of Stem Cells in the Treatment of Intervertebral Disc Degeneration

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Abstract

The paper presents a review of current data on the use of stem cells in the treatment of intervertebral disc degeneration. Acute spinal pain is often a consequence of the pathology affecting the intervertebral disc. Many applied therapeutic techniques do not provide effective results as expected because most of them address symptoms, but do not treat the underlying disease. We have outlined current findings on the molecular mechanisms of intervertebral disc degeneration, analyzed international experimental studies demonstrating the feasibility of a stem cell therapy for intervertebral disc degeneration. The conducted studies reported on the clinical application of mesenchymal stem cells or stem cells derived from adipose, synovium, and bone marrow tissue. The most pressing and undetermined issues that require further experimental and clinical studies are indicated and defined in the article.

About the authors

V. A. Byvaltsev

Irkutsk State Medical University;
Railway Clinical Hospital on the station Irkutsk-Passazhirskiy of Russian Railways Ltd.;
Irkutsk Scientific Center of Surgery and Traumatology;
Irkutsk State Academy of Postgraduate Education

Email: byval75vadim@yandex.ru
ORCID iD: 0000-0003-4349-7101
Irkutsk Russian Federation

I. A. Stepanov

Irkutsk State Medical University

Author for correspondence.
Email: edmoilers@mail.ru
ORCID iD: 0000-0001-9039-9147
Irkutsk Russian Federation

L. A. Bardonova

Irkutsk State Medical University

Email: lyudmila15@ibox.ru
Irkutsk Russian Federation

E. G. Belykh

Irkutsk State Medical University;
Irkutsk Scientific Center of Surgery and Traumatology

Email: e.belykh@yandex.ru
ORCID iD: 0000-0003-2060-5739
Irkutsk

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